Proposal Name Integrated regional and global coordination

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The model is exemplified by the recent establishment of ANDI the African Network. for Drugs and Diagnostics Innovation With a certain level of central coordination and. support similar networks are under discussion within ASEAN Association of. Southeast Asian Nations and the Americas through PAHO National networks are. also being established in China and India, The governance and operational structures will vary from region to region but. several core elements are envisaged a representation from health and science. and technology ministries b engagement of non governmental sectors both. private sector and civil society c independent scientific and technical advice with. independent peer review of funded research d thorough but light bureaucracy. This propoposal further outlines the value of this approach and addresses the. CEWG criteria, i public health enhanced local R D capacity linkage of R D to local manufacture. stimulating potential for sustainable production and access to health. ii technical feasibility ANDI has already formally been established with core. processes in place others networks are under discussion. iii financial feasibility the potential to access regional and other local funding as. well as international funding, iv cross cutting issues the regional focus leads to a holistic rather than a disease. or issue based approach This with representative governance means. that it is easier to address issues such as IP capacity building equitable. access partnership, v key steps funds and increased coordination support are the main elements. required to make this model a reality Recommendation of this approach. by the CEWG would be an important milestone, vi evidence base an increasing body of literature stresses the value of regional.
innovation of public private partnerships of networks for pharmaceutical. innovation There are peer reviewed literature reporting on the progress. of and support for this regional innovation network model. Please see references 1 2 3 4 5 6 below,Potential public health impact1 of the proposal. The network approach described here will lead to the development of more. regionally owned R D led innovation as well as more regionally led manufacturing. and production that will feed into sustainable regional public health use It will ensure. coherence and alignment of the various activities to the specific needs of developing. countries Most importantly it will support sustainable capacity and infrastructural. development as well as equitable access and delivery of health interventions in. developing countries in the medium to long term In addition to contributing to the. goals of the GSPOA this approach will facilitate the achievement of MDGs the Paris. Declaration on Aid Effectiveness and other international and regional declarations. ref 1 7 8 9 10 11, The outputs that might be developed through this approach is best exemplified by. the work of ANDI whose specific objectives and deliverables include i developing a. portfolio of high quality pharmaceutical R D projects that will result in new drugs. diagnostics vaccines medical devices and technologies to prevent and control. diseases that disproportionately affect the African continent and ensuring that these. products are manufactured and locally accessed ii supporting a network of. research centres of excellence that will share expertise knowledge and contribute to. capacity building across Africa iv brokering relationships with key stakeholders and. promoting partnerships between the public and private sectors and v facilitating. intra African and broader South South collaboration as well as North South. collaboration, Principally CEWG criterion 1 but others may be relevant e g Equity distributive effect including on. availability and affordability of products and impact on access and delivery. Steady progress has been made in the past 3 years in trying to achieve these. objectives and deliverables, i a call for proposals that was launched in the 4Q 2010 resulted in 207 applications. from all regions in Africa The initial review of the proposals has been undertaken by. the ANDI Scientific and Technical Advisory committee STAC with the short listing. of about 50 projects which have been requested to submit detailed proposals A. final review and selection of the top 5 to 10 projects for possible funding will be. undertaken later this year This is a significant step towards developing the ANDI. portfolio of quality pharmaceutical R D projects that may result in new drugs. diagnostics vaccines medical devices and technologies to prevent and control. diseases that disproportionately affect the African continent. ii The first ever call for proposals to identify and accredit Centres of Excellence. CoE across Africa based on a set of criteria and rigorous review process was. initiated last year The review of the over 117 applications received was finalized at. the 1st meeting of the ANDI STAC meeting in Addis Ababa in May 2011 A formal. announcement and recognition of the Centres will take place at the 4th ANDI. Stakeholders Meeting scheduled for 24 27 October 2011 in Addis Ababa Ethiopia. This announcement is another mechanism to recognize and reward innovation. These centres will be networked and be used to support ANDI portfolio of projects. and capacity building including training of young African scientists and researchers. It should be mentioned that these centres include both public private and non. governmental institutions in Africa and their area of work cover the entire R D value. chain including manufacturing and commercialization of products This is major. innovation that could contribute to achievement of health impact in the medium to. long term including MDGs, In addition the following have also been achieved by ANDI.
o Successful implementation of 3 major pan African stakeholders meetings the. last was held in Nairobi Kenya and attended by over 500 participants from over. 40 countries from across the globe including representatives from 30 African. countries covering all the regions ref 12 13 14, o Implementation of memorandum of understanding MoU between WHO and. UNECA to enable UNECA to host ANDI as a partnership. o The establishment of an innovative governance structure including a ministerial. level Board and an independent Scientific and Technical Advisory Committee. Development of knowledge management database, The overview of ANDI value proposition is summarized in Figure1. Figure 1 ANDI impact value proposition Highlights the potential impact of the work of ANDI in. collaboration with all stakeholders,Technical feasibility2 of the proposal. The potential to develop regional networks has already been demonstrated by ANDI. The establishment of a high level Board co chaired by the Minister of Health for. Kenya and the Minister of Science and Technology for South Africa further. exemplifies its potential significance for the region Other networks as mentioned. above are already in development, ANDI was established as an initiative under the auspices of UNECA The technical. feasibility was supported by a variety of R D landscape analysis broad consultation. in Africa and overseas which helped to identify local needs priorities as well as. opportunities and gaps ref 2 3 4 15 All these informed the establishment of ANDI. and the development of its strategic business plan ref 2 3. The strategic business plan s development involved multiple consultative. discussions analyses and over 170 stakeholder interviews. An analysis of scientific publications from 2004 to 2008 illustrates the partnering. activities of African institutions and demonstrates the potential value of an African. based network For HIV biomedical research the top 20 institutions working in or. with Africa were identified and the collaborative links of the African institutions. mapped The results shown in figure 2 demonstrate that the vast majority of African. institutional collaboration is with external institutions in the USA and Europe This. same picture is seen for other diseases disproportionately affecting Africa as well as. biomedical patent landscape ref 2 3 This extra continental collaboration in itself is. not a bad thing but there is an obvious need to further strengthen intra African. collaboration By complementing existing activities with a strengthened intra African. collaboration African innovation capacity and increased African ownership and. control of research can be better developed, Figure 2 Top collaborative linkages between African institutions in the fields of HIV AIDS.
demonstrate that over 95 of collaborations are external to Africa. Figure 3 demonstrates that basic innovation capabilities exist but also highlights the. uneven geographic nature of those capabilities By generating sub regional hubs for. a pan African network and by linking this to a governance structure that has strong. sub regional representation it is anticipated that ANDI will help leverage technology. transfer and capacity building from the stronger sub regional institutions to weaker. sub regional institutions One of ANDI s key objectives is to create networks and. synergies between African institutions that strengthen South South and North South. collaborations, Figure 3 Top centres in Africa for A biomedical research publications and B manufacturing. It is expected that a functional organization located in Africa owned managed and. governed by African institutions implementing product R D and ensuring. sustainable access to new drugs and diagnostics innovations will help fill a number. of gaps first a lack of investment in product R D within Africa second a lack of. collaboration among African scientists and between the African public and private. sector and third a lack of awareness of the link between research and economic. development, Preliminary data from Asia and South America show that significant capability exist. for innovation,Financial feasibility3 of the proposal. A recent report of G Finder ref 22 demonstrated that India Brazil and South Africa. are now among the top 12 contributors globally to the financing of R D for neglected. diseases This illustrates that there is potential for substantive financing for. innovation within regions affected by diseases that disproportionately affect. developing countries Middle income countries and emerging economies can assist. driving forward regional approaches Lower income countries are also committing. more to financing innovation and science and technology For example Tanzania. has committed to spend 1 of its GDP on science technology and innovation Such. efforts can also be reinforced by the regional development banks and the local. private sector The financing needs for ANDI have been developed in detail and are. illustrated below An estimated 30M per year would provide for the development of. a solid regional portfolio of R D projects ref 2 Figure 4. Similar business and strategic plans are under development for other networks They. give an idea of the types of resources that could generate a significant impact. The ANDI business plan outlines the creation and management of an Innovation. Fund to finance drugs and diagnostics research One idea is to create an. endowment fund in Africa that can complement other more classical donations to. generate a sustainable annual income of up to US 30 million to ANDI operation and. projects Discussions are under way with the African Development Bank to host this. fund but in the time being an ANDI Trust has been established at UNECA This plan. has been developed by a Task Force that includes partners from several national. African institutions and the African Diaspora in collaboration with WHO through. TDR the AFRO and EMRO AfDB UNECA and the EU, Figure 4 Funding requirements ANDI work on R D known The ANDI Trust Fund has been. established with the goal to establish an endowment fund for the medium long term for sustainability. How the proposal addresses cross cutting issues1, Various cross cutting issues identified in CEWG criteria are addressed below Again.
the example of ANDI s response is given, CEWG Criteria 7 IP management as highlighted in the strategic business plan ref. 2 ANDI s work covers capacity building and training for IP management in. collaboration with other agencies This is a major area of need identified during the. mapping of the R D landscape in Africa In addition ANDI is working to finalize its IP. strategy and policy in relation to concrete projects and access to products in Africa. Similar considerations would need to be addressed by other networks taking into. account their special regional issues, CEWG criteria 8 Potential for de linking R D cost and price of products some of. the existing push and pull mechanisms are aimed at achieving this objective. However at the moment these mechanisms are not integrated For example the. PDP s are doing an excellent work in R D and some products are now available on. the market However it is not always clear how the products that result from these. efforts will be made available to developing countries in an affordable and. sustainable way In particular the link to local and sustained manufacture and. delivery in developing countries is limited, Regional networks offer a strong potential to link R D to local manufacture and. PROPOSAL TEMPLATE Proposal Name Integrated regional and global coordination and financing mechanism of R amp D for diseases that disproportionately affect developing countries the ANDI model Submitted by 1 ANDI African Network for Drugs and Diagnostics Innovation United Nations Economic Commission for Africa Addis Ababa Ethiopia 2 TDR UNICEF UNDP World Bank WHO Special Programme for

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